PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butanoate
0 ImagesCat. No.: HY-W613030CAS No.: 1392140-97-4
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tert-Butyl (2-(2-(aminooxy)ethoxy)ethyl)carbamate
0 ImagesCat. No.: HY-W190869CAS No.: 1596369-00-4
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Methyl 3-iodopropiolate
0 ImagesCat. No.: HY-W251660CAS No.: 155004-90-3
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Cbz-azaspiro[3.3]heptane-OH
![Cbz-azaspiro[3.3]heptane-OH](https://file.medchemexpress.com/product_pic/hy-w057967.gif "Click to View Cbz-azaspiro[3.3]heptane-OH Product Detail")
0 ImagesCat. No.: HY-W057967CAS No.: 1363383-32-7
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1-(Piperidin-4-ylmethyl)piperidine
0 ImagesCat. No.: HY-W209253CAS No.: 32470-52-3
![tert-Butyl 7-(aminomethyl)-2-azaspiro[3.5]nonane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w063558.gif "Click to View tert-Butyl 7-(aminomethyl)-2-azaspiro[3.5]nonane-2-carboxylate Product Detail")
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2-(Piperidin-4-yl)-acetic acid ethyl ester
0 ImagesCat. No.: HY-W002927CAS No.: 59184-90-6
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N3-Aca-Aca-OH
0 ImagesCat. No.: HY-151861CAS No.: 866363-71-5
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Hydroxy-PEG3-I
0 ImagesCat. No.: HY-W077025CAS No.: 136399-06-9
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Benzyl 4-(3-hydroxypropyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W088806CAS No.: 99198-80-8
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(1R,3R)-3-Amino-2,2,4,4-tetramethylcyclobutan-1-ol phosphate
0 ImagesCat. No.: HY-W998338CAS No.: 1338812-52-4
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TsO-PEG3-NH-CO-OBn
0 ImagesCat. No.: HY-W583790CAS No.: 1451362-50-7
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(((7-Bromoheptyl)oxy)methyl)benzene
0 ImagesCat. No.: HY-W047157CAS No.: 94427-22-2
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DBCO-PEG4-NHS ester (Standard)
0 ImagesCat. No.: HY-140272RCAS No.: 1427004-19-0DBCO-PEG4-NHS ester (Standard) is the analytical standard of DBCO-PEG4-NHS ester (HY-140272). This product is intended for research and analytical applications. DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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tert-Butyl (6-oxohexyl)carbamate
0 ImagesCat. No.: HY-W612672CAS No.: 80860-42-0
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1-(5-Iodo-2-pyridinyl)-4-piperidinecarboxylic acid
0 ImagesCat. No.: HY-168200CAS No.: 2037137-82-71-(5-Iodo-2-pyridinyl)-4-piperidinecarboxylic acid is a PROTAC linker can be used in the synthesis of DYR684 (HY-168194).
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3-Hydroxypropyl 4-methylbenzenesulfonate
0 ImagesCat. No.: HY-W572064CAS No.: 81842-71-9Synonyms: TOS-PR-OH
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tert-Butyl 3-(azetidin-3-yl)pyrrolidine-1-carboxylate
0 ImagesCat. No.: HY-W093831CAS No.: 1314771-82-8
